The Buffalo Neuroimaging Analysis Center (BNAC) is a dedicated research center that has expertise in conducting studies and clinical trials using optical coherence tomography (OCT). 

Recently, OCT has been applied to the study of neurodegenerative neurological disorders, as it is a well-tolerated, inexpensive and reproducible technique that enables the study of different retinal layers, including those where neurons and axons reside. OCT is increasing our understanding how retinal dynamics can be a window into neurodegenerative central nervous system processes. A growing body of evidence supports the use of OCT measures such as peripapillary retinal nerve fiber layer thickness (pRNFLT), ganglion cell and inner plexiform layer thickness (GCIP), inner neural layer thickness (INL) and total macular volume (TMV) in the research and clinical setting, as they reliably reflect neuroaxonal damage. Indeed, some MRI and OCT studies have shown associations between reduced pRNFLT and/or GCIP with brain atrophy, supporting the role of these measures as markers of global neurodegeneration. Furthermore, pRNFLT is related to physical and functional disability, cognitive impairment, clinical and MRI evidence of disease activity, and is able to predict long term disability in disease like multiple sclerosis (MS). Similar associations have also been found with other OCT biomarkers.

For more information about OCT imaging endpoints, click here.



  • Jakimovski D, Zivadinov R, Vaughn CB, Ozel O, Weinstock-Guttman B (2021) Clinical effects associated with five-year retinal nerve fiber layer thinning in multiple sclerosis. J Neurol Sci 427:117552 [Open article]
  • Jakimovski D, Benedict RHB, Weinstock-Guttman B, Ozel O, Fuchs TA, Lincoff N, Bergsland N, Dwyer MG, Zivadinov R (2021) Visual deficits and cognitive assessment of multiple sclerosis: confounder, correlate, or both? J Neurol 268:2578-2588 [Open article]
  • Tavazzi E, Jakimovski D, Kuhle J, Hagemeier J, Ozel O, Ramanathan M, Barro C, Bergsland N, Tomic D, Kropshofer H, Leppert D, Michalak Z, Lincoff N, Dwyer MG, Benedict RHB, Weinstock-Guttman B, Zivadinov R (2020) Serum neurofilament light chain and optical coherence tomography measures in MS: A longitudinal study. Neurol Neuroimmunol Neuroinflamm  7:e737 [Open article]



Part of BNAC’s mission is to help share our tools and experience with our colleagues and other industry partners. If you need help with OCT analysis techniques in your research or clinical trial work, please reach out to discuss how we can assist. Our group brings decades of experience and expertise to every collaborative study and service partnership.