Research Studies on Iron Imaging


  • Reeves JA,G Weinstock Z, Zivadinov R, Dwyer MG, Bergsland N, Salman F, Schweser F, Weinstock-Guttman B, Benedict RHB, Jakimovski D.P Paramagnetic rim lesions are associated with greater incidence of relapse and worse cognitive recovery following relapse. Mult Scler 2023;29(8):1033-1038. [Open Article]


  • Reeves JA, G Dwyer MG, Bergsland N, Wilding GE, Jakimovski D, P Salman F, G SuleB, Meineke N, Weinstock-Guttman B, Zivadinov R, Schweser F. Susceptibility networks reveal independent patterns of iron abnormalities in multiple sclerosis. Neuroimage 2022:261:119503. [Open Article]


  • Schweser F, Hagemeier J, Dwyer MG, Bergsland N, Hametner S, Weinstock-Guttman B, Zivadinov R (2021) Decreasing brain iron in multiple sclerosis: The difference between concentration and content in iron MRI. Hum Brain Mapp 42:1463-1474 [Open article]


  • Subramanian K, Utriainen D, Ramasamy DP, et al. Longitudinal Magnetic Resonance Imaging of Cerebral Microbleeds in Multiple Sclerosis Patients. Diagnostics (Basel) 2020;10. [Open article]
  • Jakimovski D, Weinstock-Guttman B, Ramanathan M, Dwyer MG and Zivadinov R (2020). "Infections, Vaccines and Autoimmunity: A Multiple Sclerosis Perspective." Vaccines (Basel) 8(1). [Open article]


  • Bergsland N, Tavazzi E, Schweser F, Jakimovski D, Hagemeier J, Dwyer MG and Zivadinov R (2019). "Targeting Iron Dyshomeostasis for Treatment of Neurodegenerative Disorders." CNS Drugs 33(11): 1073-1086. [Open article]
  • Taege Y, Hagemeier J, Bergsland N, Dwyer MG, Weinstock-Guttman B, Zivadinov R and Schweser F (2019). "Assessment of mesoscopic properties of deep gray matter iron through a model-based simultaneous analysis of magnetic susceptibility and R2* - A pilot study in patients with multiple sclerosis and normal controls." Neuroimage 186: 308-320. [Open article]


  • Schweser F and Zivadinov R (2018). "Quantitative susceptibility mapping (QSM) with an extended physical model for MRI frequency contrast in the brain: a proof-of-concept of quantitative susceptibility and residual (QUASAR) mapping." NMR Biomed 31(12): e3999. [Open article]
  • Zivadinov R, Tavazzi E, Bergsland N, Hagemeier J, Lin F, Dwyer MG, Carl E, Kolb C, Hojnacki D, Ramasamy D, Durfee J, Weinstock-Guttman B and Schweser F (2018). "Brain Iron at Quantitative MRI Is Associated with Disability in Multiple Sclerosis." Radiology 289(2): 487-496. [Open article]
  • Schweser F, Preda M and Zivadinov R (2018). "Susceptibility Weighted MRI in Rodents at 9.4 T." Methods Mol Biol 1718: 205-234. [Open article]
  • Hagemeier J, Ramanathan M, Schweser F, Dwyer MG, Lin F, Bergsland N, Weinstock-Guttman B and Zivadinov R (2018). "Iron-related gene variants and brain iron in multiple sclerosis and healthy individuals." Neuroimage Clin 17: 530-540. [Open article]
  • Schweser F, Raffaini Duarte Martins AL, Hagemeier J, Lin F, Hanspach J, Weinstock-Guttman B, Hametner S, Bergsland N, Dwyer MG and Zivadinov R (2018). "Mapping of thalamic magnetic susceptibility in multiple sclerosis indicates decreasing iron with disease duration: A proposed mechanistic relationship between inflammation and oligodendrocyte vitality." Neuroimage 167: 438-452. [Open article]
  • Hagemeier J, Zivadinov R, Dwyer MG, Polak P, Bergsland N, Weinstock-Guttman B, Zalis J, Deistung A, Reichenbach JR and Schweser F (2018). "Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain." Neuroimage Clin 18: 1007-1016. [Open article]


  • Hanspach J, Dwyer MG, Bergsland NP, Feng X, Hagemeier J, Bertolino N, Polak P, Reichenbach JR, Zivadinov R and Schweser F (2017). "Methods for the computation of templates from quantitative magnetic susceptibility maps (QSM): Toward improved atlas- and voxel-based analyses (VBA)." J Magn Reson Imaging 46(5): 1474-1484. [Open article]
  • Feng X, Deistung A, Dwyer MG, Hagemeier J, Polak P, Lebenberg J, Frouin F, Zivadinov R, Reichenbach JR and Schweser F (2017). "An improved FSL-FIRST pipeline for subcortical gray matter segmentation to study abnormal brain anatomy using quantitative susceptibility mapping (QSM)." Magn Reson Imaging 39: 110-122. [Open article]
  • Bergsland N, Tavazzi E, Lagana MM, Baglio F, Cecconi P, Viotti S, Zivadinov R, Baselli G and Rovaris M (2017). "White Matter Tract Injury is Associated with Deep Gray Matter Iron Deposition in Multiple Sclerosis." J Neuroimaging 27(1): 107-113. [Open article]


  • Zivadinov R, Ramasamy DP, Benedict RR, Polak P, Hagemeier J, Magnano C, Dwyer MG, Bergsland N, Bertolino N, Weinstock-Guttman B, Kolb C, Hojnacki D, Utriainen D, Haacke EM and Schweser F (2016). "Cerebral Microbleeds in Multiple Sclerosis Evaluated on Susceptibility-weighted Images and Quantitative Susceptibility Maps: A Case-Control Study." Radiology 281(3): 884-895. [Open article]


  • Alexander JS, Chervenak R, Weinstock-Guttman B, Tsunoda I, Ramanathan M, Martinez N, Omura S, Sato F, Chaitanya GV, Minagar A, McGee J, Jennings MH, Monceaux C, Becker F, Cvek U, Trutschl M and Zivadinov R (2015). "Blood circulating microparticle species in relapsing-remitting and secondary progressive multiple sclerosis. A case-control, cross sectional study with conventional MRI and advanced iron content imaging outcomes." J Neurol Sci 355(1-2): 84-89. [Open article]
  • Zivadinov R, Dwyer M, Markovic-Plese S, Hayward B, Bergsland N, Heininen-Brown M, Carl E, Kennedy C, Dangond F and Weinstock-Guttman B (2015). "A pilot, longitudinal, 24-week study to evaluate the effect of interferon beta-1a subcutaneous on changes in susceptibility-weighted imaging-filtered phase assessment of lesions and subcortical deep-gray matter in relapsing-remitting multiple sclerosis." Ther Adv Neurol Disord 8(2): 59-70. [Open article]
  • Dwyer MG, Zivadinov R, Markovic-Plese S, Bergsland N, Heininen-Brown M, Carl E, Kennedy C, Weinstock-Guttman B, Hayward B and Dangond F (2015). "Associations between changes in ferritin levels and susceptibility-weighted imaging filtered phase in patients with relapsing-remitting multiple sclerosis over 24weeks of therapy with subcutaneous interferon beta-1a three times weekly." J Neuroimmunol 281: 44-50. [Open article]
  • Hagemeier J, Tong O, Dwyer MG, Schweser F, Ramanathan M and Zivadinov R (2015). "Effects of diet on brain iron levels among healthy individuals: an MRI pilot study." Neurobiol Aging 36(4): 1678-1685. [Open article]
  • Modica CM, Zivadinov R, Dwyer MG, Bergsland N, Weeks AR and Benedict RH (2015). "Iron and volume in the deep gray matter: association with cognitive impairment in multiple sclerosis." AJNR Am J Neuroradiol 36(1): 57-62. [Open article]


  • Hagemeier J, Heininen-Brown M, Gabelic T, Guttuso T, Jr., Silvestri N, Lichter D, Fugoso LE, Bergsland N, Carl E, Geurts JJ, Weinstock-Guttman B and Zivadinov R (2014). "Phase white matter signal abnormalities in patients with clinically isolated syndrome and other neurologic disorders." AJNR Am J Neuroradiol 35(10): 1916-1923. [Open article]


  • Hagemeier J, Dwyer MG, Bergsland N, Schweser F, Magnano CR, Heininen-Brown M, Ramasamy DP, Carl E, Kennedy C, Melia R, Polak P, Deistung A, Geurts JJ, Reichenbach JR and Zivadinov R (2013). "Effect of age on MRI phase behavior in the subcortical deep gray matter of healthy individuals." AJNR Am J Neuroradiol 34(11): 2144-2151. [Open article]
  • Hagemeier J, Weinstock-Guttman B, Heininen-Brown M, Poloni GU, Bergsland N, Schirda C, Magnano CR, Kennedy C, Carl E, Dwyer MG, Minagar A and Zivadinov R (2013). "Gray matter SWI-filtered phase and atrophy are linked to disability in MS." Front Biosci (Elite Ed) 5: 525-532. [Open article]
  • Hagemeier J, Yeh EA, Brown MH, Bergsland N, Dwyer MG, Carl E, Weinstock-Guttman B and Zivadinov R (2013). "Iron content of the pulvinar nucleus of the thalamus is increased in adolescent multiple sclerosis." Mult Scler 19(5): 567-576. [Open article]


  • Hagemeier J, Geurts JJ and Zivadinov R (2012). "Brain iron accumulation in aging and neurodegenerative disorders." Expert Rev Neurother 12(12): 1467-1480. [Open article]
  • Hagemeier J, Weinstock-Guttman B, Bergsland N, Heininen-Brown M, Carl E, Kennedy C, Magnano C, Hojnacki D, Dwyer MG and Zivadinov R (2012). "Iron deposition on SWI-filtered phase in the subcortical deep gray matter of patients with clinically isolated syndrome may precede structure-specific atrophy." AJNR Am J Neuroradiol 33(8): 1596-1601. [Open article]
  • Hagemeier J, Heininen-Brown M, Poloni GU, Bergsland N, Magnano CR, Durfee J, Kennedy C, Carl E, Weinstock-Guttman B, Dwyer MG and Zivadinov R (2012). "Iron deposition in multiple sclerosis lesions measured by susceptibility-weighted imaging filtered phase: a case control study." J Magn Reson Imaging 36(1): 73-83. [Open article]
  • Habib CA, Liu M, Bawany N, Garbern J, Krumbein I, Mentzel HJ, Reichenbach J, Magnano C, Zivadinov R and Haacke EM (2012). "Assessing abnormal iron content in the deep gray matter of patients with multiple sclerosis versus healthy controls." AJNR Am J Neuroradiol 33(2): 252-258. [Open article]
  • Zivadinov R, Heininen-Brown M, Schirda CV, Poloni GU, Bergsland N, Magnano CR, Durfee J, Kennedy C, Carl E, Hagemeier J, Benedict RH, Weinstock-Guttman B and Dwyer MG (2012). "Abnormal subcortical deep-gray matter susceptibility-weighted imaging filtered phase measurements in patients with multiple sclerosis: a case-control study." Neuroimage 59(1): 331-339. [Open article]


  • Zivadinov R, Weinstock-Guttman B and Pirko I (2011). "Iron deposition and inflammation in multiple sclerosis. Which one comes first?" BMC Neurosci 12: 60. [Open article]


  • Zivadinov R, Schirda C, Dwyer MG, Haacke ME, Weinstock-Guttman B, Menegatti E, Heininen-Brown M, Magnano C, Malagoni AM, Wack DS, Hojnacki D, Kennedy C, Carl E, Bergsland N, Hussein S, Poloni G, Bartolomei I, Salvi F and Zamboni P (2010). "Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis: a pilot case-control study." Int Angiol 29(2): 158-175. [Open article]