Research Studies on Iron Imaging

2025

  • Salman F, Ramesh A, Jochmann T, Prayer M, Adegbemigun A, Reeves JA, Wilding GE, Cho J, Jakimovski D, Bergsland N, Dwyer MG, Zivadinov R, Schweser F. Sensitivity of quantitative susceptibility mapping for clinical research in deep gray matter. Hum Brain Mapp 2025;46(6):e70187. [Open Article]
  • Reeves JA, Salman F, Mohebbi M, Bergsland N, Jakimovski D, Weinstock-Guttman B, Zivadinov R, Dwyer MG, Schweser F. Association between paramagnetic rim lesions and pulvinar iron depletion in persons with multiple sclerosis. Mult Scler Rel Dis 2025;93:106187. [Open Article]
  • Reeves JA, Bartnik A, Mohebbi M, Ramanathan M, Bergsland N, Jakimovski D, Wilding GE, Salman F,U Schweser F, Weinstock-Guttman B, Hojnacki D, Eckert S, Dwyer MG, Zivadinov R. Determinants of long-term paramagnetic rim lesion evolution in people with multiple sclerosis. Ann Clin Transl Sci 2025;12(2):267-279. [Open Article]

2024

  • Reeves JA, Bartnik A, Mohebbi M, Bergsland N, Jakimovski D, Salman F, Schweser F, Weinstock-Guttman B, Dwyer MG, Zivadinov R. Associations between paramagnetic rim lesion evolution and clinical and radiological disease progression in persons with multiple sclerosis. Neurology 2024:103(10):e210004. [Open Article]
  • Reeves JA, Wicks T, Mohebbi M, Jakimovski D, Bergsland N, Salman F,G Schweser F, Weinstock-Guttman B, Dwyer MG, Zivadinov R. Paramagnetic rim lesions predict greater relapse rates, but not greater disability progression, over 10 years. Mult Scler 2024;30(4-5): 535-545. [Open Article]

2023

  • Reeves JA, Weinstock Z, Zivadinov R, Dwyer MG, Bergsland N, Salman F, Schweser F, Weinstock-Guttman B, Benedict RHB, Jakimovski D. Paramagnetic rim lesions are associated with greater incidence of relapse and worse cognitive recovery following relapse. Mult Scler 2023;29(8):1033-1038. [Open Article]

2022

  • Reeves JA, G Dwyer MG, Bergsland N, Wilding GE, Jakimovski D, P Salman F, G SuleB, Meineke N, Weinstock-Guttman B, Zivadinov R, Schweser F. Susceptibility networks reveal independent patterns of iron abnormalities in multiple sclerosis. Neuroimage 2022:261:119503. [Open Article]

2021

  • Schweser F, Hagemeier J, Dwyer MG, Bergsland N, Hametner S, Weinstock-Guttman B, Zivadinov R (2021) Decreasing brain iron in multiple sclerosis: The difference between concentration and content in iron MRI. Hum Brain Mapp 42:1463-1474 [Open article]

2020

  • Subramanian K, Utriainen D, Ramasamy DP, et al. Longitudinal Magnetic Resonance Imaging of Cerebral Microbleeds in Multiple Sclerosis Patients. Diagnostics (Basel) 2020;10. [Open article]
  • Jakimovski D, Weinstock-Guttman B, Ramanathan M, Dwyer MG and Zivadinov R (2020). "Infections, Vaccines and Autoimmunity: A Multiple Sclerosis Perspective." Vaccines (Basel) 8(1). [Open article]

2019

  • Bergsland N, Tavazzi E, Schweser F, Jakimovski D, Hagemeier J, Dwyer MG and Zivadinov R (2019). "Targeting Iron Dyshomeostasis for Treatment of Neurodegenerative Disorders." CNS Drugs 33(11): 1073-1086. [Open article]
  • Taege Y, Hagemeier J, Bergsland N, Dwyer MG, Weinstock-Guttman B, Zivadinov R and Schweser F (2019). "Assessment of mesoscopic properties of deep gray matter iron through a model-based simultaneous analysis of magnetic susceptibility and R2* - A pilot study in patients with multiple sclerosis and normal controls." Neuroimage 186: 308-320. [Open article]

2018

  • Schweser F and Zivadinov R (2018). "Quantitative susceptibility mapping (QSM) with an extended physical model for MRI frequency contrast in the brain: a proof-of-concept of quantitative susceptibility and residual (QUASAR) mapping." NMR Biomed 31(12): e3999. [Open article]
  • Zivadinov R, Tavazzi E, Bergsland N, Hagemeier J, Lin F, Dwyer MG, Carl E, Kolb C, Hojnacki D, Ramasamy D, Durfee J, Weinstock-Guttman B and Schweser F (2018). "Brain Iron at Quantitative MRI Is Associated with Disability in Multiple Sclerosis." Radiology 289(2): 487-496. [Open article]
  • Schweser F, Preda M and Zivadinov R (2018). "Susceptibility Weighted MRI in Rodents at 9.4 T." Methods Mol Biol 1718: 205-234. [Open article]
  • Hagemeier J, Ramanathan M, Schweser F, Dwyer MG, Lin F, Bergsland N, Weinstock-Guttman B and Zivadinov R (2018). "Iron-related gene variants and brain iron in multiple sclerosis and healthy individuals." Neuroimage Clin 17: 530-540. [Open article]
  • Schweser F, Raffaini Duarte Martins AL, Hagemeier J, Lin F, Hanspach J, Weinstock-Guttman B, Hametner S, Bergsland N, Dwyer MG and Zivadinov R (2018). "Mapping of thalamic magnetic susceptibility in multiple sclerosis indicates decreasing iron with disease duration: A proposed mechanistic relationship between inflammation and oligodendrocyte vitality." Neuroimage 167: 438-452. [Open article]
  • Hagemeier J, Zivadinov R, Dwyer MG, Polak P, Bergsland N, Weinstock-Guttman B, Zalis J, Deistung A, Reichenbach JR and Schweser F (2018). "Changes of deep gray matter magnetic susceptibility over 2 years in multiple sclerosis and healthy control brain." Neuroimage Clin 18: 1007-1016. [Open article]

2017

  • Hanspach J, Dwyer MG, Bergsland NP, Feng X, Hagemeier J, Bertolino N, Polak P, Reichenbach JR, Zivadinov R and Schweser F (2017). "Methods for the computation of templates from quantitative magnetic susceptibility maps (QSM): Toward improved atlas- and voxel-based analyses (VBA)." J Magn Reson Imaging 46(5): 1474-1484. [Open article]
  • Feng X, Deistung A, Dwyer MG, Hagemeier J, Polak P, Lebenberg J, Frouin F, Zivadinov R, Reichenbach JR and Schweser F (2017). "An improved FSL-FIRST pipeline for subcortical gray matter segmentation to study abnormal brain anatomy using quantitative susceptibility mapping (QSM)." Magn Reson Imaging 39: 110-122. [Open article]
  • Bergsland N, Tavazzi E, Lagana MM, Baglio F, Cecconi P, Viotti S, Zivadinov R, Baselli G and Rovaris M (2017). "White Matter Tract Injury is Associated with Deep Gray Matter Iron Deposition in Multiple Sclerosis." J Neuroimaging 27(1): 107-113. [Open article]

2016

  • Zivadinov R, Ramasamy DP, Benedict RR, Polak P, Hagemeier J, Magnano C, Dwyer MG, Bergsland N, Bertolino N, Weinstock-Guttman B, Kolb C, Hojnacki D, Utriainen D, Haacke EM and Schweser F (2016). "Cerebral Microbleeds in Multiple Sclerosis Evaluated on Susceptibility-weighted Images and Quantitative Susceptibility Maps: A Case-Control Study." Radiology 281(3): 884-895. [Open article]

2015

  • Alexander JS, Chervenak R, Weinstock-Guttman B, Tsunoda I, Ramanathan M, Martinez N, Omura S, Sato F, Chaitanya GV, Minagar A, McGee J, Jennings MH, Monceaux C, Becker F, Cvek U, Trutschl M and Zivadinov R (2015). "Blood circulating microparticle species in relapsing-remitting and secondary progressive multiple sclerosis. A case-control, cross sectional study with conventional MRI and advanced iron content imaging outcomes." J Neurol Sci 355(1-2): 84-89. [Open article]
  • Zivadinov R, Dwyer M, Markovic-Plese S, Hayward B, Bergsland N, Heininen-Brown M, Carl E, Kennedy C, Dangond F and Weinstock-Guttman B (2015). "A pilot, longitudinal, 24-week study to evaluate the effect of interferon beta-1a subcutaneous on changes in susceptibility-weighted imaging-filtered phase assessment of lesions and subcortical deep-gray matter in relapsing-remitting multiple sclerosis." Ther Adv Neurol Disord 8(2): 59-70. [Open article]
  • Dwyer MG, Zivadinov R, Markovic-Plese S, Bergsland N, Heininen-Brown M, Carl E, Kennedy C, Weinstock-Guttman B, Hayward B and Dangond F (2015). "Associations between changes in ferritin levels and susceptibility-weighted imaging filtered phase in patients with relapsing-remitting multiple sclerosis over 24weeks of therapy with subcutaneous interferon beta-1a three times weekly." J Neuroimmunol 281: 44-50. [Open article]
  • Hagemeier J, Tong O, Dwyer MG, Schweser F, Ramanathan M and Zivadinov R (2015). "Effects of diet on brain iron levels among healthy individuals: an MRI pilot study." Neurobiol Aging 36(4): 1678-1685. [Open article]
  • Modica CM, Zivadinov R, Dwyer MG, Bergsland N, Weeks AR and Benedict RH (2015). "Iron and volume in the deep gray matter: association with cognitive impairment in multiple sclerosis." AJNR Am J Neuroradiol 36(1): 57-62. [Open article]

2014

  • Hagemeier J, Heininen-Brown M, Gabelic T, Guttuso T, Jr., Silvestri N, Lichter D, Fugoso LE, Bergsland N, Carl E, Geurts JJ, Weinstock-Guttman B and Zivadinov R (2014). "Phase white matter signal abnormalities in patients with clinically isolated syndrome and other neurologic disorders." AJNR Am J Neuroradiol 35(10): 1916-1923. [Open article]

2013

  • Hagemeier J, Dwyer MG, Bergsland N, Schweser F, Magnano CR, Heininen-Brown M, Ramasamy DP, Carl E, Kennedy C, Melia R, Polak P, Deistung A, Geurts JJ, Reichenbach JR and Zivadinov R (2013). "Effect of age on MRI phase behavior in the subcortical deep gray matter of healthy individuals." AJNR Am J Neuroradiol 34(11): 2144-2151. [Open article]
  • Hagemeier J, Weinstock-Guttman B, Heininen-Brown M, Poloni GU, Bergsland N, Schirda C, Magnano CR, Kennedy C, Carl E, Dwyer MG, Minagar A and Zivadinov R (2013). "Gray matter SWI-filtered phase and atrophy are linked to disability in MS." Front Biosci (Elite Ed) 5: 525-532. [Open article]
  • Hagemeier J, Yeh EA, Brown MH, Bergsland N, Dwyer MG, Carl E, Weinstock-Guttman B and Zivadinov R (2013). "Iron content of the pulvinar nucleus of the thalamus is increased in adolescent multiple sclerosis." Mult Scler 19(5): 567-576. [Open article]

2012

  • Hagemeier J, Geurts JJ and Zivadinov R (2012). "Brain iron accumulation in aging and neurodegenerative disorders." Expert Rev Neurother 12(12): 1467-1480. [Open article]
  • Hagemeier J, Weinstock-Guttman B, Bergsland N, Heininen-Brown M, Carl E, Kennedy C, Magnano C, Hojnacki D, Dwyer MG and Zivadinov R (2012). "Iron deposition on SWI-filtered phase in the subcortical deep gray matter of patients with clinically isolated syndrome may precede structure-specific atrophy." AJNR Am J Neuroradiol 33(8): 1596-1601. [Open article]
  • Hagemeier J, Heininen-Brown M, Poloni GU, Bergsland N, Magnano CR, Durfee J, Kennedy C, Carl E, Weinstock-Guttman B, Dwyer MG and Zivadinov R (2012). "Iron deposition in multiple sclerosis lesions measured by susceptibility-weighted imaging filtered phase: a case control study." J Magn Reson Imaging 36(1): 73-83. [Open article]
  • Habib CA, Liu M, Bawany N, Garbern J, Krumbein I, Mentzel HJ, Reichenbach J, Magnano C, Zivadinov R and Haacke EM (2012). "Assessing abnormal iron content in the deep gray matter of patients with multiple sclerosis versus healthy controls." AJNR Am J Neuroradiol 33(2): 252-258. [Open article]
  • Zivadinov R, Heininen-Brown M, Schirda CV, Poloni GU, Bergsland N, Magnano CR, Durfee J, Kennedy C, Carl E, Hagemeier J, Benedict RH, Weinstock-Guttman B and Dwyer MG (2012). "Abnormal subcortical deep-gray matter susceptibility-weighted imaging filtered phase measurements in patients with multiple sclerosis: a case-control study." Neuroimage 59(1): 331-339. [Open article]

2011

  • Zivadinov R, Weinstock-Guttman B and Pirko I (2011). "Iron deposition and inflammation in multiple sclerosis. Which one comes first?" BMC Neurosci 12: 60. [Open article]

2010

  • Zivadinov R, Schirda C, Dwyer MG, Haacke ME, Weinstock-Guttman B, Menegatti E, Heininen-Brown M, Magnano C, Malagoni AM, Wack DS, Hojnacki D, Kennedy C, Carl E, Bergsland N, Hussein S, Poloni G, Bartolomei I, Salvi F and Zamboni P (2010). "Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis: a pilot case-control study." Int Angiol 29(2): 158-175. [Open article]