The Buffalo Neuroimaging Analysis Center (BNAC) is a dedicated research center that has expertise in radiologically isolated syndrome (RIS) and clinically isolated syndrome (CIS) clinical trials. BNAC has been involved in many research studies and clinical trials investigating clinical features, biomarkers, as well predictive value of and imaging endpoints in subjects with RIS and CIS. Our work was one of the first in the field to emphasize the role of deep gray matter (thalamus) and cortical pathology at these earliest stages of MS.

For more information about imaging endpoints, click here.

Featured Recent Clinical Studies in FEATURED RECENT CLINICAL STUDIES IN RIS/CIS

  • Zivadinov R, Dwyer MG, Carl E, Poole EM, Cavalier S, Briassouli P, Bergsland N (2020) Slowing of brain atrophy with teriflunomide and delayed conversion to clinically definite MS. Ther Adv Neurol Disord 13:1756286420970754 [Open article]
  • Gabelic T, Ramasamy DP, Weinstock-Guttman B, Hagemeier J, Kennedy C, Melia R, Hojnacki D, Ramanathan M, Zivadinov R (2014) Prevalence of radiologically isolated syndrome and white matter signal abnormalities in healthy relatives of patients with multiple sclerosis. AJNR Am J Neuroradiol 35:106-112 [Open article]
  • Zivadinov R, Havrdova E, Bergsland N, Tyblova M, Hagemeier J, Seidl Z, Dwyer MG, Vaneckova M, Krasensky J, Carl E, Kalincik T, Horakova D (2013) Thalamic atrophy is associated with development of clinically definite multiple sclerosis. Radiology 268:831-841 [Open article]

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CONTACT OUR TEAM TODAY

Part of BNAC’s mission is to help share our tools and experience with our colleagues and other industry partners. If you need help with managing a medical imaging trial related to RIS/CIS, please reach out to discuss how we can assist. Our group brings decades of experience and expertise to every collaborative study and service partnership.  

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