Research Studies in RIS/CIS

 

 

2020

  • Zivadinov R, Dwyer MG, Carl E, et al. Slowing of brain atrophy with teriflunomide and delayed conversion to clinically definite MS. Ther Adv Neurol Disord 2020;13:1756286420970754. [Open article]
  • Tavazzi E, Bergsland N, Kuhle J, et al. A multimodal approach to assess the validity of atrophied T2-lesion volume as an MRI marker of disease progression in multiple sclerosis. J Neurol 2020;267:802-811. [Open article]
  • Jakimovski D, Bergsland N, Dwyer MG, et al. Serum Neurofilament Light Chain Levels are Associated with Lower Thalamic Perfusion in Multiple Sclerosis. Diagnostics (Basel) 2020;10.

2019

  • Genovese AV, Hagemeier J, Bergsland N, Jakimovski D, Dwyer MG, Ramasamy DP, Lizarraga AA, Hojnacki D, Kolb C, Weinstock-Guttman B and Zivadinov R (2019). "Atrophied Brain T2 Lesion Volume at MRI Is Associated with Disability Progression and Conversion to Secondary Progressive Multiple Sclerosis." Radiology 293(2): 424-433. [Open article]
  • Jakimovski D, Weinstock-Guttman B, Gandhi S, Guan Y, Hagemeier J, Ramasamy DP, Fuchs TA, Browne RW, Bergsland N, Dwyer MG, Ramanathan M and Zivadinov R (2019). "Dietary and lifestyle factors in multiple sclerosis progression: results from a 5-year longitudinal MRI study." J Neurol 266(4): 866-875. [Open article]

2018

  • Ghione E, Bergsland N, Dwyer MG, Hagemeier J, Jakimovski D, Paunkoski I, Ramasamy DP, Silva D, Carl E, Hojnacki D, Kolb C, Weinstock-Guttman B and Zivadinov R (2018). "Brain Atrophy Is Associated with Disability Progression in Patients with MS followed in a Clinical Routine." AJNR Am J Neuroradiol 39(12): 2237-2242. [Open article]
  • Dwyer MG, Bergsland N, Ramasamy DP, Jakimovski D, Weinstock-Guttman B and Zivadinov R (2018). "Atrophied Brain Lesion Volume: A New Imaging Biomarker in Multiple Sclerosis." J Neuroimaging 28(5): 490-495. [Open article]
  • Zivadinov R, Ramasamy DP, Hagemeier J, Kolb C, Bergsland N, Schweser F, Dwyer MG, Weinstock-Guttman B and Hojnacki D (2018). "Evaluation of Leptomeningeal Contrast Enhancement Using Pre-and Postcontrast Subtraction 3D-FLAIR Imaging in Multiple Sclerosis." AJNR Am J Neuroradiol 39(4): 642-647. [Open article]
  • Jakimovski D, Kolb C, Ramanathan M, Zivadinov R and Weinstock-Guttman B (2018). "Interferon beta for Multiple Sclerosis." Cold Spring Harb Perspect Med 8(11). [Open article]
  • Schweser F, Raffaini Duarte Martins AL, Hagemeier J, Lin F, Hanspach J, Weinstock-Guttman B, Hametner S, Bergsland N, Dwyer MG and Zivadinov R (2018). "Mapping of thalamic magnetic susceptibility in multiple sclerosis indicates decreasing iron with disease duration: A proposed mechanistic relationship between inflammation and oligodendrocyte vitality." Neuroimage 167: 438-452. [Open article]

2017

  • Uher T, Havrdova E, Sobisek L, Krasensky J, Vaneckova M, Seidl Z, Tyblova M, Ramasamy D, Zivadinov R and Horakova D (2017). "Is no evidence of disease activity an achievable goal in MS patients on intramuscular interferon beta-1a treatment over long-term follow-up?" Mult Scler 23(2): 242-252. [Open article]

2016

  • Schwartz CE, Dwyer MG, Benedict R, Weinstock-Guttman B, Bergsland NP, Li J, Ramanathan M and Zivadinov R (2016). "Reserve-related activities and MRI metrics in multiple sclerosis patients and healthy controls: an observational study." BMC Neurol 16: 108. [Open article]
  • Zivadinov R, Ramasamy DP, Benedict RR, Polak P, Hagemeier J, Magnano C, Dwyer MG, Bergsland N, Bertolino N, Weinstock-Guttman B, Kolb C, Hojnacki D, Utriainen D, Haacke EM and Schweser F (2016). "Cerebral Microbleeds in Multiple Sclerosis Evaluated on Susceptibility-weighted Images and Quantitative Susceptibility Maps: A Case-Control Study." Radiology 281(3): 884-895. [Open article]
  • Zivadinov R, Cerza N, Hagemeier J, Carl E, Badgett D, Ramasamy DP, Weinstock-Guttman B and Ramanathan M (2016). "Humoral response to EBV is associated with cortical atrophy and lesion burden in patients with MS." Neurol Neuroimmunol Neuroinflamm 3(1): e190. [Open article]
  • Uher T, Horakova D, Tyblova M, Zeman D, Krasulova E, Mrazova K, Seidl Z, Vaneckova M, Krasensky J, Weinstock-Guttman B, Ramanathan M, Havrdova E and Zivadinov R (2016). "Increased albumin quotient (QAlb) in patients after first clinical event suggestive of multiple sclerosis is associated with development of brain atrophy and greater disability 48 months later." Mult Scler 22(6): 770-781. [Open article]
  • Kappus N, Weinstock-Guttman B, Hagemeier J, Kennedy C, Melia R, Carl E, Ramasamy DP, Cherneva M, Durfee J, Bergsland N, Dwyer MG, Kolb C, Hojnacki D, Ramanathan M and Zivadinov R (2016). "Cardiovascular risk factors are associated with increased lesion burden and brain atrophy in multiple sclerosis." J Neurol Neurosurg Psychiatry 87(2): 181-187. [Open article]

2015

  • Graziano E, Hagemeier J, Weinstock-Guttman B, Ramasamy DP and Zivadinov R (2015). "Increased contrast enhancing lesion activity in relapsing-remitting multiple sclerosis migraine patients." Neuroimage Clin 9: 110-116. [Open article]
  • Schwartz CE, Ayandeh A, Ramanathan M, Benedict R, Dwyer MG, Weinstock-Guttman B and Zivadinov R (2015). "Reserve-building activities in multiple sclerosis patients and healthy controls: a descriptive study." BMC Neurol 15: 135. [Open article]
  • Fellows K, Uher T, Browne RW, Weinstock-Guttman B, Horakova D, Posova H, Vaneckova M, Seidl Z, Krasensky J, Tyblova M, Havrdova E, Zivadinov R and Ramanathan M (2015). "Protective associations of HDL with blood-brain barrier injury in multiple sclerosis patients." J Lipid Res 56(10): 2010-2018. [Open article]
  • Varosanec M, Uher T, Horakova D, Hagemeier J, Bergsland N, Tyblova M, Seidl Z, Vaneckova M, Krasensky J, Dwyer MG, Havrdova E and Zivadinov R (2015). "Longitudinal Mixed-Effect Model Analysis of the Association between Global and Tissue-Specific Brain Atrophy and Lesion Accumulation in Patients with Clinically Isolated Syndrome." AJNR Am J Neuroradiol 36(8): 1457-1464. [Open article]
  • Uher T, Horakova D, Kalincik T, Bergsland N, Tyblova M, Ramasamy DP, Seidl Z, Vaneckova M, Krasensky J, Havrdova E and Zivadinov R (2015). "Early magnetic resonance imaging predictors of clinical progression after 48 months in clinically isolated syndrome patients treated with intramuscular interferon beta-1a." Eur J Neurol 22(7): 1113-1123. [Open article]

2014

  • Uher T, Benedict RH, Horakova D, Bergsland N, Dusankova JB, Tyblova M, Ramasamy DP, Seidl Z, Vaneckova M, Krasensky J, Havrdova E and Zivadinov R (2014). "Relationship between gray matter volume and cognitive learning in CIS patients on disease-modifying treatment." J Neurol Sci 347(1-2): 229-234. [Open article]
  • Uher T, Horakova D, Bergsland N, Tyblova M, Ramasamy DP, Seidl Z, Vaneckova M, Krasensky J, Havrdova E and Zivadinov R (2014). "MRI correlates of disability progression in patients with CIS over 48 months." Neuroimage Clin 6: 312-319. [Open article]
  • Uher T, Blahova-Dusankova J, Horakova D, Bergsland N, Tyblova M, Benedict RH, Kalincik T, Ramasamy DP, Seidl Z, Hagermeier J, Vaneckova M, Krasensky J, Havrdova E and Zivadinov R (2014). "Longitudinal MRI and neuropsychological assessment of patients with clinically isolated syndrome." J Neurol 261(9): 1735-1744. [Open article]
  • Browne RW, Weinstock-Guttman B, Zivadinov R, Horakova D, Bodziak ML, Tamano-Blanco M, Badgett D, Tyblova M, Vaneckova M, Seidl Z, Krasensky J, Bergsland N, Ramasamy DP, Hagemeier J, Qu J, Havrdova E and Ramanathan M (2014). "Serum lipoprotein composition and vitamin D metabolite levels in clinically isolated syndromes: Results from a multi-center study." J Steroid Biochem Mol Biol 143: 424-433. [Open article]
  • Zivadinov R, Chin J, Horakova D, Bergsland N, Weinstock-Guttman B, Tamano-Blanco M, Badgett D, Hagemeier J, Tyblova M, Carl E, Krasensky J, Vaneckova M, Seidl Z, Dwyer MG, Havrdova E and Ramanathan M (2014). "Humoral responses to herpesviruses are associated with neurodegeneration after a demyelinating event: results from the multi-center set study." J Neuroimmunol 273(1-2): 58-64. [Open article]
  • Hagemeier J, Heininen-Brown M, Gabelic T, Guttuso T, Jr., Silvestri N, Lichter D, Fugoso LE, Bergsland N, Carl E, Geurts JJ, Weinstock-Guttman B and Zivadinov R (2014). "Phase white matter signal abnormalities in patients with clinically isolated syndrome and other neurologic disorders." AJNR Am J Neuroradiol 35(10): 1916-1923. [Open article]
  • Browne RW, Weinstock-Guttman B, Horakova D, Zivadinov R, Bodziak ML, Tamano-Blanco M, Badgett D, Tyblova M, Vaneckova M, Seidl Z, Krasensky J, Bergsland N, Ramasamy DP, Hagemeier J, Havrdova E and Ramanathan M (2014). "Apolipoproteins are associated with new MRI lesions and deep grey matter atrophy in clinically isolated syndromes." J Neurol Neurosurg Psychiatry 85(8): 859-864. [Open article]
  • Cappellani R, Bergsland N, Weinstock-Guttman B, Kennedy C, Carl E, Ramasamy DP, Hagemeier J, Dwyer MG, Patti F and Zivadinov R (2014). "Diffusion tensor MRI alterations of subcortical deep gray matter in clinically isolated syndrome." J Neurol Sci 338(1-2): 128-134. [Open article]
  • Gabelic T, Ramasamy DP, Weinstock-Guttman B, Hagemeier J, Kennedy C, Melia R, Hojnacki D, Ramanathan M and Zivadinov R (2014). "Prevalence of radiologically isolated syndrome and white matter signal abnormalities in healthy relatives of patients with multiple sclerosis." AJNR Am J Neuroradiol 35(1): 106-112. [Open article]

2013

  • Weinstock-Guttman B, Horakova D, Zivadinov R, Tamano-Blanco M, Badgett D, Tyblova M, Vaneckova M, Seidl Z, Krasensky J, Bergsland N, Ramasamy DP, Hagemeier J, Havrdova E and Ramanathan M (2013). "Interactions of serum cholesterol with anti-herpesvirus responses affect disease progression in clinically isolated syndromes." J Neuroimmunol 263(1-2): 121-127. [Open article]
  • Zivadinov R, Havrdova E, Bergsland N, Tyblova M, Hagemeier J, Seidl Z, Dwyer MG, Vaneckova M, Krasensky J, Carl E, Kalincik T and Horakova D (2013). "Thalamic atrophy is associated with development of clinically definite multiple sclerosis." Radiology 268(3): 831-841. [Open article]
  • Weinstock-Guttman B, Zivadinov R, Horakova D, Havrdova E, Qu J, Shyh G, Lakota E, O'Connor K, Badgett D, Tamano-Blanco M, Tyblova M, Hussein S, Bergsland N, Willis L, Krasensky J, Vaneckova M, Seidl Z and Ramanathan M (2013). "Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event." J Neurol Neurosurg Psychiatry 84(11): 1186-1191. [Open article]
  • Horakova D, Zivadinov R, Weinstock-Guttman B, Havrdova E, Qu J, Tamano-Blanco M, Badgett D, Tyblova M, Bergsland N, Hussein S, Willis L, Krasensky J, Vaneckova M, Seidl Z, Lelkova P, Dwyer MG, Zhang M, Yu H, Duan X, Kalincik T and Ramanathan M (2013). "Environmental factors associated with disease progression after the first demyelinating event: results from the multi-center SET study." PLoS One 8(1): e53996. [Open article]
  • Tipirneni A, Weinstock-Guttman B, Ramanathan M, Abdelrahman N, Hussein S, Hagemeier J, Durfee J, Teter BE, Hojnacki D, Dwyer MG and Zivadinov R (2013). "MRI characteristics of familial and sporadic multiple sclerosis patients." Mult Scler 19(9): 1145-1152. [Open article]

2012

  • Magnano C, Schirda C, Weinstock-Guttman B, Wack DS, Lindzen E, Hojnacki D, Bergsland N, Kennedy C, Belov P, Dwyer MG, Poloni GU, Beggs CB and Zivadinov R (2012). "Cine cerebrospinal fluid imaging in multiple sclerosis." J Magn Reson Imaging 36(4): 825-834. [Open article]
  • Bergsland N, Horakova D, Dwyer MG, Dolezal O, Seidl ZK, Vaneckova M, Krasensky J, Havrdova E and Zivadinov R (2012). "Subcortical and cortical gray matter atrophy in a large sample of patients with clinically isolated syndrome and early relapsing-remitting multiple sclerosis." AJNR Am J Neuroradiol 33(8): 1573-1578. [Open article]
  • Hagemeier J, Weinstock-Guttman B, Bergsland N, Heininen-Brown M, Carl E, Kennedy C, Magnano C, Hojnacki D, Dwyer MG and Zivadinov R (2012). "Iron deposition on SWI-filtered phase in the subcortical deep gray matter of patients with clinically isolated syndrome may precede structure-specific atrophy." AJNR Am J Neuroradiol 33(8): 1596-1601. [Open article]
  • Hagemeier J, Heininen-Brown M, Poloni GU, Bergsland N, Magnano CR, Durfee J, Kennedy C, Carl E, Weinstock-Guttman B, Dwyer MG and Zivadinov R (2012). "Iron deposition in multiple sclerosis lesions measured by susceptibility-weighted imaging filtered phase: a case control study." J Magn Reson Imaging 36(1): 73-83. [Open article]

2011

  • Horakova D, Zivadinov R, Weinstock-Guttman B, Havrdova E, Tamano-Blanco M, Tyblova M, Hussein S, Bergsland N, Willis L, Krasensky J, Vaneckova M, Seidl Z, Lelkova P and Ramanathan M (2011). "HLA DRB1*1501 is only modestly associated with lesion burden at the first demyelinating event." J Neuroimmunol 236(1-2): 76-80. [Open article]
  • Zivadinov R, Marr K, Cutter G, Ramanathan M, Benedict RH, Kennedy C, Elfadil M, Yeh AE, Reuther J, Brooks C, Hunt K, Andrews M, Carl E, Dwyer MG, Hojnacki D and Weinstock-Guttman B (2011). "Prevalence, sensitivity, and specificity of chronic cerebrospinal venous insufficiency in MS." Neurology 77(2): 138-144. [Open article]

2009

  • Ramasamy DP, Benedict RH, Cox JL, Fritz D, Abdelrahman N, Hussein S, Minagar A, Dwyer MG and Zivadinov R (2009). "Extent of cerebellum, subcortical and cortical atrophy in patients with MS: a case-control study." J Neurol Sci 282(1-2): 47-54. [Open article]
  • Antulov R, Weinstock-Guttman B, Cox JL, Hussein S, Durfee J, Caiola C, Dwyer MG, Bergsland N, Abdelrahman N, Stosic M, Hojnacki D, Munschauer FE, Miletic D and Zivadinov R (2009). "Gender-related differences in MS: a study of conventional and nonconventional MRI measures." Mult Scler 15(3): 345-354. [Open article]

2008

  • Zivadinov R, Banas AC, Yella V, Abdelrahman N, Weinstock-Guttman B and Dwyer MG (2008). "Comparison of three different methods for measurement of cervical cord atrophy in multiple sclerosis." AJNR Am J Neuroradiol 29(2): 319-325. [Open article]

2007

  • Garg N, Zivadinov R, Ramanathan M, Vasiliu I, Locke J, Watts K, Lema J, Rajeswary J, Munschauer FE, Ambrus J, Jr. and Weinstock-Guttman B (2007). "Clinical and MRI correlates of autoreactive antibodies in multiple sclerosis patients." J Neuroimmunol 187(1-2): 159-165. [Open article]
  • Tavazzi E, Dwyer MG, Weinstock-Guttman B, Lema J, Bastianello S, Bergamaschi R, Cosi V, Benedict RH, Munschauer FE, 3rd and Zivadinov R (2007). "Quantitative diffusion weighted imaging measures in patients with multiple sclerosis." Neuroimage 36(3): 746-754. [Open article]

2006

  • Zivadinov R and Sepcic J (2006). "[Use of magnetic resonance imaging in the diagnosis and prognosis of multiple sclerosis]." Lijec Vjesn 128(9-10): 295-308. [Open article]