PRLs are a Marker of a More Aggressive Ongoing Disease Course and may be a Valuable Use in Clinical Trials
A recent study conducted by a BNAC research team led by Jack Reeves, a Ph.D. candidate, showed that an imaging marker called “paramagnetic rim lesions” predicts greater multiple sclerosis (MS) related disability progression and clinical relapse frequency over 10 years.
The team studied 172 people with multiple sclerosis, using a specialized iron-sensitive neuroimaging technique called “Quantitative Susceptibility Mapping” to detect paramagnetic magnetic rim lesions in people with MS. The team then related number of paramagnetic rim lesions to subsequent disability worsening and rate of clinical relapse.
These results provide evidence that PRLs are a marker of a more aggressive ongoing disease course and may be a valuable for use in clinical trials.
The study was detailed in an article published by SAGE Publications Inc.
Researchers: Jack A Reeves, Maryam Mohebbi, Taylor Wicks, Fahad Salman, Alexander Bartnik, PhD, Dejan Jakimovski, MD, PhD, Niels Bergsland, PhD, Ferdinand Schweser, PhD, Bianca Weinstock-Guttman, MD, Michael G Dwyer, PhD and Robert Zivadinov, MD, PhD
