Selected Research Studies on Brain Atrophy

2021

  • Uher T, Krasenky J, Malpas C, Bergsland N, Dwyer MG, Kubala Havrdova E, Vaneckova M, Horakova D, Zivadinov R, Kalincik T (2021) Evolution of Brain Volume Loss Rates in Early Stages of Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm 8 [Open article]
  • Jakimovski D, Zivadinov R, Bergsland N, Ramasamy DP, Hagemeier J, Genovese AV, Hojnacki D, Weinstock-Guttman B, Dwyer MG (2021) Clinical feasibility of longitudinal lateral ventricular volume measurements on T2-FLAIR across MRI scanner changes. NeuroImage Clinical 29:102554 [Open article]

2020

  • Uher T, Bergsland N, Krasensky J, Dwyer MG, Andelova M, Sobisek L, Havrdova EK, Horakova D, Zivadinov R, Vaneckova M (2020) Interpretation of Brain Volume Increase in Multiple Sclerosis. J Neuroimaging [Open article]
  • Bergsland N, Benedict RHB, Dwyer MG, Fuchs TA, Jakimovski D, Schweser F, Tavazzi E, Weinstock-Guttman B, Zivadinov R (2020) Thalamic Nuclei Volumes and Their Relationships to Neuroperformance in Multiple Sclerosis: A Cross-Sectional Structural MRI Study. J Magn Reson Imaging:e27389 [Open article]
  • Ghione E, Bergsland N, Dwyer MG, Hagemeier J, Jakimovski D, Ramasamy DP, Hojnacki D, Lizarraga AA, Kolb C, Eckert S, Weinstock-Guttman B, Zivadinov R (2020) Disability Improvement Is Associated with Less Brain Atrophy Development in Multiple Sclerosis. AJNR Am J Neuroradiol 41:1577-1583 [Open article]
  • Jakimovski D, Zivadinov R, Bergsland N, Ramasamy DP, Hagemeier J, Weinstock-Guttman B, Kolb C, Hojnacki D, Dwyer MG (2020) Sex-Specific Differences in Life Span Brain Volumes in Multiple Sclerosis. J Neuroimaging 30:342-350 [Open article]
  • Jakimovski D, Bergsland N, Dwyer MG, Hagemeier J, Ramasamy DP, Szigeti K, Guttuso T, Lichter D, Hojnacki D, Weinstock-Guttman B, Benedict RHB, Zivadinov R (2020) Long-standing multiple sclerosis neurodegeneration: volumetric magnetic resonance imaging comparison to Parkinson's disease, mild cognitive impairment, Alzheimer's disease, and elderly healthy controls. Neurobiol Aging 90:84-92 [Open article]
  • Ghione E, Bergsland N, Dwyer MG, et al. Disability Improvement Is Associated with Less Brain Atrophy Development in Multiple Sclerosis. AJNR Am J Neuroradiol 2020;41:1577-1583. [Open article]
  • Jakimovski D, Zivadinov R, Bergsland N, et al. Sex-Specific Differences in Life Span Brain Volumes in Multiple Sclerosis. J Neuroimaging 2020;30:342-350.
  • Jakimovski D, Bergsland N, Dwyer MG, et al. Long-standing multiple sclerosis neurodegeneration: volumetric magnetic resonance imaging comparison to Parkinson's disease, mild cognitive impairment, Alzheimer's disease, and elderly healthy controls. Neurobiol Aging 2020;90:84-92.
  • Jacobsen C, Zivadinov R, Myhr KM, Dalaker TO, Dalen I, Bergsland N and Farbu E (2020). "Brain atrophy and employment in multiple sclerosis patients: a 10-year follow-up study." Mult Scler J Exp Transl Clin 6(1): 2055217320902481. [Open article]
  • Tavazzi E, Bergsland N, Kuhle J, et al. A multimodal approach to assess the validity of atrophied T2-lesion volume as an MRI marker of disease progression in multiple sclerosis. J Neurol 2020;267:802-811. [Open article]
  • Fuchs TA, Benedict RH, Wilding G, et al. Trait Conscientiousness predicts rate of brain atrophy in multiple sclerosis. Mult Scler 2020;26:1433-1436. [Open article]

2019

  • Jakimovski D, Kuhle J, Ramanathan M, Barro C, Tomic D, Hagemeier J, Kropshofer H, Bergsland N, Leppert D, Dwyer MG, Michalak Z, Benedict RHB, Weinstock-Guttman B and Zivadinov R (2019). "Serum neurofilament light chain levels associations with gray matter pathology: a 5-year longitudinal study." Ann Clin Transl Neurol 6(9): 1757-1770. [Open article]
  • Genovese AV, Hagemeier J, Bergsland N, Jakimovski D, Dwyer MG, Ramasamy DP, Lizarraga AA, Hojnacki D, Kolb C, Weinstock-Guttman B and Zivadinov R (2019). "Atrophied Brain T2 Lesion Volume at MRI Is Associated with Disability Progression and Conversion to Secondary Progressive Multiple Sclerosis." Radiology 293(2): 424-433. [Open article]
  • Zivadinov R, Horakova D, Bergsland N, Hagemeier J, Ramasamy DP, Uher T, Vaneckova M, Havrdova E and Dwyer MG (2019). "A Serial 10-Year Follow-Up Study of Atrophied Brain Lesion Volume and Disability Progression in Patients with Relapsing-Remitting MS." AJNR Am J Neuroradiol 40(3): 446-452. [Open article]
  • Ghione E, Bergsland N, Dwyer MG, Hagemeier J, Jakimovski D, Paunkoski I, Ramasamy DP, Carl E, Hojnacki D, Kolb C, Weinstock-Guttman B and Zivadinov R (2019). "Aging and Brain Atrophy in Multiple Sclerosis." J Neuroimaging 29(4): 527-535. [Open article]

2018

  • Dwyer MG, Bergsland N, Ramasamy DP, Jakimovski D, Weinstock-Guttman B and Zivadinov R (2018). "Atrophied Brain Lesion Volume: A New Imaging Biomarker in Multiple Sclerosis." J Neuroimaging 28(5): 490-495. [Open article]
  • Zivadinov R, Bergsland N and Dwyer MG (2018). "Atrophied brain lesion volume, a magnetic resonance imaging biomarker for monitoring neurodegenerative changes in multiple sclerosis." Quant Imaging Med Surg 8(10): 979-983. [Open article]
  • Uher T, Krasensky J, Sobisek L, Seidl Z, Bergsland N, Dwyer MG, Kubala Havrdova E, Zivadinov R, Horakova D and Vaneckova M (2018). "The Role of High-Frequency MRI Monitoring in the Detection of Brain Atrophy in Multiple Sclerosis." J Neuroimaging 28(3): 328-337. [Open article]
  • Ghione E, Bergsland N, Dwyer MG, Hagemeier J, Jakimovski D, Paunkoski I, Ramasamy DP, Silva D, Carl E, Hojnacki D, Kolb C, Weinstock-Guttman B and Zivadinov R (2018). "Brain Atrophy Is Associated with Disability Progression in Patients with MS followed in a Clinical Routine." AJNR Am J Neuroradiol 39(12): 2237-2242. [Open article]

2017

  • Uher T, Krasensky J, Vaneckova M, Sobisek L, Seidl Z, Havrdova E, Bergsland N, Dwyer MG, Horakova D and Zivadinov R (2017). "A Novel Semiautomated Pipeline to Measure Brain Atrophy and Lesion Burden in Multiple Sclerosis: A Long-Term Comparative Study." J Neuroimaging 27(6): 620-629. [Open article]
  • Belov P, Magnano C, Krawiecki J, Hagemeier J, Bergsland N, Beggs C and Zivadinov R (2017). "Age-related brain atrophy may be mitigated by internal jugular vein enlargement in male individuals without neurologic disease." Phlebology 32(2): 125-134. [Open article]
  • Uher T, Vaneckova M, Sobisek L, Tyblova M, Seidl Z, Krasensky J, Ramasamy D, Zivadinov R, Havrdova E, Kalincik T and Horakova D (2017). "Combining clinical and magnetic resonance imaging markers enhances prediction of 12-year disability in multiple sclerosis." Mult Scler 23(1): 51-61. [Open article]

2016

  • Bergsland N, Zivadinov R, Dwyer MG, Weinstock-Guttman B and Benedict RH (2016). "Localized atrophy of the thalamus and slowed cognitive processing speed in MS patients." Mult Scler 22(10): 1327-1336. [Open article]
  • Zivadinov R, Dwyer MG and Bergsland N (2016). "Brain atrophy measurements should be used to guide therapy monitoring in MS - YES." Mult Scler 22(12): 1522-1524. [Open article]
  • Zivadinov R, Uher T, Hagemeier J, Vaneckova M, Ramasamy DP, Tyblova M, Bergsland N, Seidl Z, Dwyer MG, Krasensky J, Havrdova E and Horakova D (2016). "A serial 10-year follow-up study of brain atrophy and disability progression in RRMS patients." Mult Scler 22(13): 1709-1718. [Open article]
  • Zivadinov R, Jakimovski D, Gandhi S, Ahmed R, Dwyer MG, Horakova D, Weinstock-Guttman B, Benedict RR, Vaneckova M, Barnett M and Bergsland N (2016). "Clinical relevance of brain atrophy assessment in multiple sclerosis. Implications for its use in a clinical routine." Expert Rev Neurother: 1-17. [Open article]

2015

  • Uher T, Horakova D, Kalincik T, Bergsland N, Tyblova M, Ramasamy DP, Seidl Z, Vaneckova M, Krasensky J, Havrdova E and Zivadinov R (2015). "Early magnetic resonance imaging predictors of clinical progression after 48 months in clinically isolated syndrome patients treated with intramuscular interferon beta-1a." Eur J Neurol 22(7): 1113-1123. [Open article]
  • Varosanec M, Uher T, Horakova D, Hagemeier J, Bergsland N, Tyblova M, Seidl Z, Vaneckova M, Krasensky J, Dwyer MG, Havrdova E and Zivadinov R (2015). "Longitudinal Mixed-Effect Model Analysis of the Association between Global and Tissue-Specific Brain Atrophy and Lesion Accumulation in Patients with Clinically Isolated Syndrome." AJNR Am J Neuroradiol 36(8): 1457-1464. [Open article]

2014

  • Uher T, Benedict RH, Horakova D, Bergsland N, Dusankova JB, Tyblova M, Ramasamy DP, Seidl Z, Vaneckova M, Krasensky J, Havrdova E and Zivadinov R (2014). "Relationship between gray matter volume and cognitive learning in CIS patients on disease-modifying treatment." J Neurol Sci 347(1-2): 229-234. [Open article]
  • Jacobsen C, Hagemeier J, Myhr KM, Nyland H, Lode K, Bergsland N, Ramasamy DP, Dalaker TO, Larsen JP, Farbu E and Zivadinov R (2014). "Brain atrophy and disability progression in multiple sclerosis patients: a 10-year follow-up study." J Neurol Neurosurg Psychiatry 85(10): 1109-1115. [Open article]
  • Uher T, Horakova D, Bergsland N, Tyblova M, Ramasamy DP, Seidl Z, Vaneckova M, Krasensky J, Havrdova E and Zivadinov R (2014). "MRI correlates of disability progression in patients with CIS over 48 months." Neuroimage Clin 6: 312-319. [Open article]

2013

  • Zivadinov R, Havrdova E, Bergsland N, Tyblova M, Hagemeier J, Seidl Z, Dwyer MG, Vaneckova M, Krasensky J, Carl E, Kalincik T and Horakova D (2013). "Thalamic atrophy is associated with development of clinically definite multiple sclerosis." Radiology 268(3): 831-841. [Open article]
  • Benedict RH, Hulst HE, Bergsland N, Schoonheim MM, Dwyer MG, Weinstock-Guttman B, Geurts JJ and Zivadinov R (2013). "Clinical significance of atrophy and white matter mean diffusivity within the thalamus of multiple sclerosis patients." Mult Scler 19(11): 1478-1484. [Open article]
  • Zivadinov R, Bergsland N, Dolezal O, Hussein S, Seidl Z, Dwyer MG, Vaneckova M, Krasensky J, Potts JA, Kalincik T, Havrdova E and Horakova D (2013). "Evolution of Cortical and Thalamus Atrophy and Disability Progression in Early Relapsing-Remitting MS during 5 Years." AJNR Am J Neuroradiol 34(10): 1931-1939. [Open article]
  • Minagar A, Barnett MH, Benedict RH, Pelletier D, Pirko I, Sahraian MA, Frohman E and Zivadinov R (2013). "The thalamus and multiple sclerosis: modern views on pathologic, imaging, and clinical aspects." Neurology 80(2): 210-219. [Open article]
  • Dolezal O, Gabelic T, Horakova D, Bergsland N, Dwyer MG, Seidl Z, Krasensky J, Ramasamy DP, Vaneckova M, Havrdova E and Zivadinov R (2013). "Development of gray matter atrophy in relapsing-remitting multiple sclerosis is not gender dependent: Results of a 5-year follow-up study." Clin Neurol Neurosurg 115 Suppl 1: S42-48. [Open article]
  • Zivadinov R, Tekwe C, Bergsland N, Dolezal O, Havrdova E, Krasensky J, Dwyer MG, Seidl Z, Ramasamy DP, Vaneckova M and Horakova D (2013). "Bimonthly Evolution of Cortical Atrophy in Early Relapsing-Remitting Multiple Sclerosis over 2 Years: A Longitudinal Study." Mult Scler Int 2013: 231345. [Open article]

2012

  • Bergsland N, Horakova D, Dwyer MG, Dolezal O, Seidl ZK, Vaneckova M, Krasensky J, Havrdova E and Zivadinov R (2012). "Subcortical and cortical gray matter atrophy in a large sample of patients with clinically isolated syndrome and early relapsing-remitting multiple sclerosis." AJNR Am J Neuroradiol 33(8): 1573-1578. [Open article]
  • Batista S, Zivadinov R, Hoogs M, Bergsland N, Heininen-Brown M, Dwyer MG, Weinstock-Guttman B and Benedict RH (2012). "Basal ganglia, thalamus and neocortical atrophy predicting slowed cognitive processing in multiple sclerosis." J Neurol 259(1): 139-146. [Open article]
  • Zivadinov R and Pirko I (2012). "Advances in understanding gray matter pathology in multiple sclerosis: are we ready to redefine disease pathogenesis?" BMC Neurol 12: 9. [Open article]

2011

  • Ramasamy DP, Ramanathan M, Cox JL, Antulov R, Weinstock-Guttman B, Bergsland N, Benedict RH, Dwyer MG, Minagar A and Zivadinov R (2011). "Effect of Met66 allele of the BDNF rs6265 SNP on regional gray matter volumes in patients with multiple sclerosis: A voxel-based morphometry study." Pathophysiology 18(1): 53-60. [Open article]

2010

  • Weinstock-Guttman B, Ramanathan M, Hashmi K, Abdelrahman N, Hojnacki D, Dwyer MG, Hussein S, Bergsland N, Munschauer FE and Zivadinov R (2010). "Increased tissue damage and lesion volumes in African Americans with multiple sclerosis." Neurology 74(7): 538-544. [Open article]

2009

  • Zivadinov R, Weinstock-Guttman B, Hashmi K, Abdelrahman N, Stosic M, Dwyer M, Hussein S, Durfee J and Ramanathan M (2009). "Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis." Neurology 73(7): 504-510. [Open article]
  • Zivadinov R and Minagar A (2009). "Evidence for gray matter pathology in multiple sclerosis: a neuroimaging approach." J Neurol Sci 282(1-2): 1-4. [Open article]
  • Ramasamy DP, Benedict RH, Cox JL, Fritz D, Abdelrahman N, Hussein S, Minagar A, Dwyer MG and Zivadinov R (2009). "Extent of cerebellum, subcortical and cortical atrophy in patients with MS: a case-control study." J Neurol Sci 282(1-2): 47-54. [Open article]
  • Horakova D, Dwyer MG, Havrdova E, Cox JL, Dolezal O, Bergsland N, Rimes B, Seidl Z, Vaneckova M and Zivadinov R (2009). "Gray matter atrophy and disability progression in patients with early relapsing-remitting multiple sclerosis: a 5-year longitudinal study." J Neurol Sci 282(1-2): 112-119. [Open article]
  • Antulov R, Weinstock-Guttman B, Cox JL, Hussein S, Durfee J, Caiola C, Dwyer MG, Bergsland N, Abdelrahman N, Stosic M, Hojnacki D, Munschauer FE, Miletic D and Zivadinov R (2009). "Gender-related differences in MS: a study of conventional and nonconventional MRI measures." Mult Scler 15(3): 345-354. [Open article]

2008

  • Horakova D, Cox JL, Havrdova E, Hussein S, Dolezal O, Cookfair D, Dwyer MG, Seidl Z, Bergsland N, Vaneckova M and Zivadinov R (2008). "Evolution of different MRI measures in patients with active relapsing-remitting multiple sclerosis over 2 and 5 years: a case-control study." J Neurol Neurosurg Psychiatry 79(4): 407-414. [Open article]

2007

  • Zivadinov R, Weinstock-Guttman B, Benedict R, Tamano-Blanco M, Hussein S, Abdelrahman N, Durfee J and Ramanathan M (2007). "Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor." Hum Mol Genet 16(22): 2659-2668. [Open article]

2005

  • Benedict RH, Zivadinov R, Carone DA, Weinstock-Guttman B, Gaines J, Maggiore C, Sharma J, Tomassi MA and Bakshi R (2005). "Regional lobar atrophy predicts memory impairment in multiple sclerosis." AJNR Am J Neuroradiol 26(7): 1824-1831. [Open article]
  • Zivadinov R (2005). "Steroids and brain atrophy in multiple sclerosis." J Neurol Sci 233(1-2): 73-81. [Open article]
  • Zivadinov R, Grop A, Sharma J, Bratina A, Tjoa CW, Dwyer M and Zorzon M (2005). "Reproducibility and accuracy of quantitative magnetic resonance imaging techniques of whole-brain atrophy measurement in multiple sclerosis." J Neuroimaging 15(1): 27-36. [Open article]

2004

  • Locatelli L, Zivadinov R, Grop A and Zorzon M (2004). "Frontal parenchymal atrophy measures in multiple sclerosis." Mult Scler 10(5): 562-568. [Open article]
  • Zivadinov R, Bagnato F, Nasuelli D, Bastianello S, Bratina A, Locatelli L, Watts K, Finamore L, Grop A, Dwyer M, Catalan M, Clemenzi A, Millefiorini E, Bakshi R and Zorzon M (2004). "Short-term brain atrophy changes in relapsing-remitting multiple sclerosis." J Neurol Sci 223(2): 185-193. [Open article]
  • Sanfilipo MP, Benedict RH, Zivadinov R and Bakshi R (2004). "Correction for intracranial volume in analysis of whole brain atrophy in multiple sclerosis: the proportion vs. residual method." Neuroimage 22(4): 1732-1743. [Open article]
  • Zivadinov R and Bakshi R (2004). "Central nervous system atrophy and clinical status in multiple sclerosis." J Neuroimaging 14(3 Suppl): 27S-35S. [Open article]
  • Zivadinov R and Bakshi R (2004). "Role of MRI in multiple sclerosis I: inflammation and lesions." Front Biosci 9: 665-683. [Open article]
  • Zivadinov R and Bakshi R (2004). "Role of MRI in multiple sclerosis II: brain and spinal cord atrophy." Front Biosci 9: 647-664. [Open article]

2003

  • Fabiano AJ, Sharma J, Weinstock-Guttman B, Munschauer FE, 3rd, Benedict RH, Zivadinov R and Bakshi R (2003). "Thalamic involvement in multiple sclerosis: a diffusion-weighted magnetic resonance imaging study." J Neuroimaging 13(4): 307-314. [Open article]
  • Zivadinov R, Locatelli L, Stival B, Bratina A, Grop A, Nasuelli D, Brnabic-Razmilic O and Zorzon M (2003). "Normalized regional brain atrophy measurements in multiple sclerosis." Neuroradiology 45(11): 793-798. [Open article]

2002

  • Zivadinov R and Zorzon M (2002). "Is gadolinium enhancement predictive of the development of brain atrophy in multiple sclerosis? A review of the literature." J Neuroimaging 12(4): 302-309. [Open article]

2001

  • Zivadinov R, Sepcic J, Nasuelli D, De Masi R, Bragadin LM, Tommasi MA, Zambito-Marsala S, Moretti R, Bratina A, Ukmar M, Pozzi-Mucelli RS, Grop A, Cazzato G and Zorzon M (2001). "A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing-remitting multiple sclerosis." J Neurol Neurosurg Psychiatry 70(6): 773-780. [Open article]