As part of the University at Buffalo, we are dedicated to high quality academic research, with a focus on translational use of quantitative neuroimaging metrics in neurological diseases and disorders like MS, Alzheimer’s, and stroke. We have published over 500 scholarly articles in peer-reviewed journals.
We provide cutting-edge quantitative outcome analytics for clinical and preclinical researchers and sponsors. We combine standards-based approaches with research expertise to deliver accurate, precise measures in compliance with regulatory oversight.
A key part of our mission at BNAC is to teach. We disseminate knowledge and train future neuroimagers, trained masters, and PhD students. We host fellowships for visiting doctors and research scholars. BNAC faculty have mentored and co-mentored hundreds of PhD students, MSc students, MD students, undergraduate students, neuroimaging fellows, and neurology residents.
Precise, advanced neuroimaging metrics to measure treatment effects while maximizing statistical power.
Full coordination with participating imaging centers from study initiation, individual site on-boarding, image acquisition, and analysis.
Strict adherence to the highest standards and regulatory requirements, including FDA/EMA, GCP, and ISO 9001:2015.
Buffalo Neuroimaging Analysis Center (BNAC) director and University at Buffalo Professor of Neurology Robert Zivadinov, MD, PhD, is among six UB faculty honored as recipients of the 2022 State University of New York Chancellor’s Award for Excellence in Scholarship and Creative Activities. The SUNY system-wide Chancellor’s Awards recognize “consistently superior professional achievement and the ongoing pursuit of excellence” and the award for Excellence in Scholarship and Creative Activities specifically recognizes “those who engage actively in scholarly and creative pursuits beyond their teaching responsibilities.”
Initiating MS Research Breakthroughs While Building on Consensus
In a recent University at Buffalo’s Department of Neurology “Grand Rounds” presentation to research colleagues, doctoral candidates, and other students, BNAC Director Robert Zivadinov, MD, PhD, provided a comprehensive discussion of how a combination of traditional and novel imaging methods open the door wider to targeting microglia activation as a viable MS therapy. New imaging methods used in the study make it possible or easier to reliably assess microglia activation in living patients in addition to guiding pharmaceutical companies developing new microglia-focused MS treatments.
Zivadinov and his BNAC colleagues are delivering therapy-accelerating imaging of microglia activation, a long-trusted but hard-to-measure biomarker for secondary-progressive multiple sclerosis (SPMS). Currently it is not possible to predict who will eventually develop SPMS in which lost or damaged nerves worsen MS symptoms.
The first head-to-head comparison using microglia imaging of two FDA-approved disease-modifying treatments (DMTs) for multiple sclerosis is underway. Watch Center Director Robert Zivadinov, MD, PhD explain a study underway at the Buffalo Neuroimaging Analysis Center (BNAC) on NeurologyLive®.
The Annette Funicello Research Fund for Neurological Diseases (AFRFND) has awarded a $100,000 challenge grant to the Buffalo Neuroimaging Analysis Center (BNAC) in support of the center’s groundbreaking study of people with advanced-stage progressive Multiple Sclerosis. The grant is part of an ongoing campaign that, so far, has raised over $400,000 toward the overall goal of $1 million to underwrite this multi-year, investigator-initiated study.
Time Course of Lesion-induced Atrophy in Multiple Sclerosis.
-April 8, 2022
The University at Buffalo is extremely proud of BNAC. Throughout it’s 20-year history, BNAC’s team of multidisciplinary investigators have consistently maintained funded research programs that have used innovative neuroimaging techniques to make seminal discoveries impacting the care of patients with neurological diseases. BNAC has and is making a difference
Michael E. Cain, MD, Vice President for Health Sciences and, Dean, Jacobs School of Medicine and Biomedical Sciences
BNAC’s world class research is an enormous asset for the region by attracting major funding to University at Buffalo and advancing the field of neuroimaging. The partnership between BNAC, the Clinical and Translational Science Institute and the Center for Biomedical Imaging has completely transformed translational imaging for our researchers.
Timothy F. Murphy MD, SUNY Distinguished Professor, Director, UB Clinical and Translational Science Institute
At Bristol-Myers Squibb we have been fortunate to engage with BNAC in scientific collaborations and clinical trials. Over the last 20 years, Prof. Zivadinov and his team have consistently demonstrated their passion for innovation demonstrated by their multiple publications, oral presentations and expert forums they participate in. Being at the fore front of science in neuro-imaging, BNAC scientist have developed technologies that compete amongst the best in the field and produce reliable, on-time, analysis that helps us in industry deliver innovative clinical trials for patients. As one of the best imaging centers in the world, BNAC has truly made a positive impact in neuro-imaging, we look forward to continuing drive medical discoveries with them.
Diego G. Silva, MS, VP Global Medical Head – Neurology
During the past 10 years, I have had a great opportunity to collaborate with Prof. Zivadinov and BNAC on a variety of clinical programs in the multiple sclerosis research arena. I have found the BNAC team to be very innovative in their way of thinking, and to always be applying the cutting edge of science and technology in their imaging capabilities. Moreover, their capacity to conduct various projects is multi-faceted and unique, as they are able to address critical questions in drug development and neuroimaging by various preclinical and clinical innovative explorations. The output from BNAC is always high quality, accurate, and on time. BNAC is not only able to deliver high quality project outputs, but equally so to present and publish the results at key conferences and in high quality medical journals, which helps drive forward the science of neuroimaging.
– Davorka Tomic, Senior Medical Director, Merck Group
One of the impressive characteristics of Dr. Zivadinov and his team at BNAC is the attentive ear given to people with MS – intently listening and incorporating concerns into their research pursuits. BNAC’s patient-centric focus fosters hope in those battling MS, providing assurance that their opinions matter, and that their needs are relevant in shaping today’s research. Perhaps it stems from a long history of leading MS outcomes in Buffalo, with pioneering efforts by Dr. Larry Jacobs who championed an intent focus on his patients to groundbreaking treatment that became a global standard. BNAC maintains a strong patient focus, un-wavered by contrary opinions or less popular fields of study. Their latest research initiative, CASA-MS, showcases this high regard for the patient. Collaboratively aligned with some of the best clinicians in today’s field, BNAC pursues translational research and patient guided outcomes that make a real difference for individuals with multiple sclerosis.
Larry A. Montani, BNAC Advisory Council Chair
It is an incredible opportunity to contribute to research projects in a multi-disciplinary neuroimaging lab with such an impressive scientific track record and to start my neuroscientific career with meaningful publications in translational research at BNAC.
Franziska E. Hildesheim, MRI Research Fellow