## PREPROCESSING

- Transfer and storage of MRI scans from various MRI acquisition centers
- Preprocessing per scan, including:
- Image sorting
- Inhomogeneity correction
- Noise reduction
- Conversion of image format
- Coregistration
- Database creation and export to SPSS or Excel file

**LESION MEASURES**

**LESION MEASURES**

- Calculation of lesion activity (new, enlarging, recurrent, persistent) and scan activity
- Calculation of number and volume of Gd-enhancing lesions
- Calculation of number and volume of T2 lesions
- Calculation of number and volume of T1 hypointense lesions
- Calculation of lesion morphology
- Calculation of lesion spatial distribution
- Calculation of lesion histogram matching
- Calculation of voxel-wise based dynamic lesion changes

**ATROPHY MEASURES**

**ATROPHY MEASURES**

- Calculation of cross-sectional and longitudinal brain atrophy, gray, and white matter atrophy
- Calculation of regional parenchyma brain atrophy (SABRE, Freesurfer, VBM))
- Calculation of regional linear atrophy measures (third ventricular width, bicaudate ratio, lateral ventricularvolum, and callosal atrophy)
- MRI iron measure analysis

**MAGNETIZATION TRANSFER MEASURES**

**MAGNETIZATION TRANSFER MEASURES**

- Calculation of global magnetization transfer ratio (MTR) in different tissue compartments
- Calculation of regional MTR in different tissue compartments

**DIFFUSION IMAGING MEASURES**

**DIFFUSION IMAGING MEASURES**

- Calculation of mean diffusivity
- Calculation of entrophy
- Calculation of fractional anisotrophy
- Calculation of axial and radial diffusivity
- Calculation of tractography measures

**PERFUSION IMAGING MEASURES**

**PERFUSION IMAGING MEASURES**

- Calculation of mean transit time
- Calculation of cerebral blood flow
- Calculation of cerebral blood volume integration

**SPECTROSCOPY IMAGING MEASURES**

**SPECTROSCOPY IMAGING MEASURES**

- Calculation of N-acetyl aspartate
- Calculation of stem cell peak
- Calculation of choline
- Calculation of creatine
- Calculation of other lipid peaks

**fMRI MEASURES**

**fMRI MEASURES**

- Record onset times/behavioral data
- Processing utilizing SPM software
- Preprocessing (realignment, slice timing correction, coregistration, normalization and smoothing)
- Calculation of activated voxels
- Individual analyses (scan montages and MNI coordinates)
- Group analyses (scan montage and MNI coordinates)
- Small volume correction (limit analysis to interest areas)

- Overlap maps (the summary of binary maps extracted from individual data)
- Correlational analyses
- Incorporation of phase correction/ field maps

- Anatomical labels utilizing Talairach
- fMRI for purposes of presurgical planning

**SUSCEPTIBILITY-WEIGHTED IMAGING MEASURES**

**SUSCEPTIBILITY-WEIGHTED IMAGING MEASURES**

- MRI Iron measure analysis

**CEREBROSPINAL FLUID IMAGING MEASURES**

**CEREBROSPINAL FLUID IMAGING MEASURES**

- Net flow
- Retrograde flow
- Antegrade flow
- Peak retrograde flow
- Peak antegrade flow
- Aqueduct axis length

**SPINAL CORD MEASURES**

**SPINAL CORD MEASURES**

- Calculation of number and volume of T2, T1, and GD lesions
- Calculation of spinal cord atrophy
- Calculation of magnetization transfer ratio
- Calculation of spinal cord diffusion measures

**OPTIC NERVE MEASURES**

**OPTIC NERVE MEASURES**

- Calculation of number and volume of T2, T1, and GD lesions
- Calculation of optic nerve atrophy
- Calculation of magnetization transfer ratio
- Calculation of optic nerve diffusion measures (mean diffusivity,fractional anisotropy, and entropy)

**DOPPLER MEASURES**

**DOPPLER MEASURES**

- Internal Jugular Veins
- CSA measured in upright and supine position
- ΔCSA calculated – difference between supine and upright CSA
- Velocity measured at point of CSA measurement

- Vertebral Veins
- AP diameter measured between cervical processes
- Velocity measured at point of AP diameter measurement
- Volume calculation

- Third Ventricle
- Width of third ventricle measured in upright and supine position
- Calculation of ΔIII Ventricle – difference between supine and upright width

- Straight Sinus
- Velocity measured

**OTHER SERVICES**

**OTHER SERVICES**

- PET-MRI combined analysis
- SPECT-MRI combined analysis
- Susceptibility weighted imaging (SWI)
- Assist with development of MRI sequences and protocols
- Development of MRI software programs, web-based programs, and slide animations