PREPROCESSING

  • Transfer and storage of MRI scans from various MRI acquisition centers
  • Preprocessing per scan, including:
    • Image sorting
    • Inhomogeneity correction
    • Noise reduction
    • Conversion of image format
    • Coregistration
    • Database creation and export to SPSS or Excel file

LESION MEASURES

  • Calculation of lesion activity (new, enlarging, recurrent, persistent) and scan activity
  • Calculation of number and volume of Gd-enhancing lesions
  • Calculation of number and volume of T2 lesions
  • Calculation of number and volume of T1 hypointense lesions
  • Calculation of lesion morphology
  • Calculation of lesion spatial distribution
  • Calculation of lesion histogram matching
  • Calculation of voxel-wise based dynamic lesion changes

ATROPHY MEASURES

  • Calculation of cross-sectional and longitudinal brain atrophy, gray, and white matter atrophy
  • Calculation of regional parenchyma brain atrophy (SABRE, Freesurfer, VBM))
  • Calculation of regional linear atrophy measures (third ventricular width, bicaudate ratio, lateral ventricularvolum, and callosal atrophy)
  • MRI iron measure analysis

MAGNETIZATION TRANSFER MEASURES

  • Calculation of global magnetization transfer ratio (MTR) in different tissue compartments
  • Calculation of regional MTR in different tissue compartments

DIFFUSION IMAGING MEASURES

  • Calculation of mean diffusivity
  • Calculation of entrophy
  • Calculation of fractional anisotrophy
  • Calculation of axial and radial diffusivity
  • Calculation of tractography measures

PERFUSION IMAGING MEASURES

  • Calculation of mean transit time
  • Calculation of cerebral blood flow
  • Calculation of cerebral blood volume integration

SPECTROSCOPY IMAGING MEASURES

  • Calculation of N-acetyl aspartate
  • Calculation of stem cell peak
  • Calculation of choline
  • Calculation of creatine
  • Calculation of other lipid peaks

fMRI MEASURES

  • Record onset times/behavioral data
  • Processing utilizing SPM software
    • Preprocessing (realignment, slice timing correction, coregistration, normalization and smoothing)
    • Calculation of activated voxels
      • Individual analyses (scan montages and MNI coordinates)
      • Group analyses (scan montage and MNI coordinates)
      • Small volume correction (limit analysis to interest areas)
    • Overlap maps (the summary of binary maps extracted from individual data)
    • Correlational analyses
    • Incorporation of phase correction/ field maps
  • Anatomical labels utilizing Talairach
  • fMRI for purposes of presurgical planning

SUSCEPTIBILITY-WEIGHTED IMAGING MEASURES

  • MRI Iron measure analysis

CEREBROSPINAL FLUID IMAGING MEASURES

  • Net flow
  • Retrograde flow
  • Antegrade flow
  • Peak retrograde flow
  • Peak antegrade flow
  • Aqueduct axis length

SPINAL CORD MEASURES

  • Calculation of number and volume of T2, T1, and GD lesions
  • Calculation of spinal cord atrophy
  • Calculation of magnetization transfer ratio
  • Calculation of spinal cord diffusion measures

OPTIC NERVE MEASURES

  • Calculation of number and volume of T2, T1, and GD lesions
  • Calculation of optic nerve atrophy
  • Calculation of magnetization transfer ratio
  • Calculation of optic nerve diffusion measures (mean diffusivity,fractional anisotropy, and entropy)

DOPPLER MEASURES

  • Internal Jugular Veins
    • CSA measured in upright and supine position
    • ΔCSA calculated – difference between supine and upright CSA
    • Velocity measured at point of CSA measurement
  • Vertebral Veins
    • AP diameter measured between cervical processes
    • Velocity measured at point of AP diameter measurement
    • Volume calculation
  • Third Ventricle
    • Width of third ventricle measured in upright and supine position
    • Calculation of ΔIII Ventricle – difference between supine and upright width
  • Straight Sinus
    • Velocity measured

OTHER SERVICES

  • PET-MRI combined analysis
  • SPECT-MRI combined analysis
  • Susceptibility weighted imaging (SWI)
  • Assist with development of MRI sequences and protocols
  • Development of MRI software programs, web-based programs, and slide animations