Magnetization transfer imaging (MTI) is a valuable supplement to conventional MRI imaging. While conventional imaging provides macroscopic detail of focal white matter lesions and non-focal disease such as atrophy, MTI adds the ability to microscopically examine pathology occurring both within lesions and diffusely throughout the brain parenchyma. Like certain conventional imaging sequences, MTI requires extensive post-processing to generate clinically useful data. These post-processing steps can introduce error and are often a stumbling point for the use of MTI in multi-center clinical trials.

The Buffalo Neuroimaging Analysis Center (BNAC) has extensively researched automated methods for calculation of magnetization transfer (MT) values. These methods have proven robust and highly reproducible, greatly diminishing error and making quantitative MT imaging a viable marker for clinical trials.